|“||Yes! A high school sleepover? Maybe having a sister is exciting.||”|
- Alex Hook as Frankie Gaines
- Sophia Forest as Jenny Gaines
- Carrie Schroeder as Sigourney Gaines
- Michael Laurino as Will Gaines
- James D. Ballard as Mr. Kingston
- Nicole Alyse Nelson as Dayton Reyes
- Mohana Krishnan as Tammy Gilroy
- Uriel Baldesco as Lucia Baxter
- Carson Rowland as Cole Reyes
- Armani Barrett as Byron Patrick
- Kristi Beckett as Makayla
- Mark Jacobson as PEGS1 (voice)
- Joy Kigin as Ms. Hough
- Tracy A. Johnson as EGG Lab Engineer
- Tay Lindsey as EGG Lab Engineer
- Rachael Thompson as Engineer Anderson
- Victor Jones as Mr. Manhart
| To view the I am...My Enemy's Friend? gallery, click here.
- Frankie made clothes for the first time.
- Frankie gave Cole a tip to study Algebra by telling him to simplify fractions first.
- Frankie and Tammy made a deal saying that if Frankie joined Brain Squad, she must not tell anyone about her secret eDiary.
- Tammy was reluctant about letting Dayton come to the sleepover.
- Frankie learned how to pillow fight for the first time.
- Engineer Andersen was able to track down where Frankie and her family were at.
- Cole tried to get Frankie to celebrate with him, but failed to do so.
- Tammy's secret e-diary was found on Dayton's phone, but was deleted by Frankie.
- Frankie and Dayton were using chemicals to get the coffee stain out of Dayton's shirt, but failed to do so.
- Dayton's father gave Dayton the shirt (that Dayton got a coffee stain on) and it was special to Dayton.
- Frankie can snap pictures of others using her eyes.
- Sigourney at first didn't agree to allow Frankie to have a sleepover, but after when Will said that if Frankie canceled the sleepover, Tammy was going to be even more suspicious, she agreed to let Frankie have one.
- Cole made Tammy apologize to Frankie.
- When Tammy was apologizing to Frankie, she found out that Frankie read her super-secret eDiary.
- Hairball Potter and Permione Granger, was a reference to the two characters from the Harry Potter series. Harry Potter and Hermione Granger.